Cesena to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Cesena and arrive at Siracusa every about 2 hours on average. If travelling with Trenitalia, you need to know the Cesena to Syracuse train schedule: the first train leaves at 08:24, while the last ride is at 23:00. A Cesena to Syracuse train cost about 98.1 €. But how long is the train ride from Cesena to Syracuse? Your journey takes about 18 hours on average.