Città di Castello to Frosinone trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Arezzo, Roma Tiburtina and arrive at Frosinone every about 1 hour on average. If travelling with Trenitalia, you need to know the Città di Castello to Frosinone train schedule: the first train leaves at 04:25, while the last ride is at 16:13. A Città di Castello to Frosinone train cost about 5.4 €. But how long is the train ride from Città di Castello to Frosinone? Your journey takes about 4 hours on average.