Città di Castello to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Arezzo and arrive at Niscemi every about 2 hours on average. If travelling with Trenitalia, you need to know the Città di Castello to Niscemi train schedule: the first train leaves at 07:25, while the last ride is at 22:53. A Città di Castello to Niscemi train cost about 88.6 €. But how long is the train ride from Città di Castello to Niscemi? Your journey takes about 17 hours on average.