Città di Castello to Niscemi trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 6 daily rides to get from Città di Castello to Niscemi. Trains leave from Arezzo and arrive at Niscemi every about 2 hours on average. The trip by train from Città di Castello to Niscemi last on average 00:52 travelling with high-speed trains (Frecciarossa or Italotreno) If travelling with Trenitalia, you need to know the Città di Castello to Niscemi train schedule: the first train leaves at 07:25, while the last ride is at 22:53. A Città di Castello to Niscemi train cost about 88.6 €. But how long is the train ride from Città di Castello to Niscemi? Your journey takes about 17 hours on average.