Città di Castello to Palermo trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 4 daily rides to get from Città di Castello to Palermo. Trains leave from Arezzo and arrive at Palermo Notarbartolo every about 3 hours on average. If travelling with Trenitalia, you need to know the Città di Castello to Palermo train schedule: the first train leaves at 18:13, while the last ride is at 22:53. A Città di Castello to Palermo train cost about 92.95 €. But how long is the train ride from Città di Castello to Palermo? Your journey takes about 19 hours on average.