Città di Castello to Ragusa trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 2 daily rides to get from Città di Castello to Ragusa. Trains leave from Arezzo and arrive at Ragusa every about 6 hours on average. If travelling with Trenitalia, you need to know the Città di Castello to Ragusa train schedule: the first train leaves at 04:25, while the last ride is at 04:25. A Città di Castello to Ragusa train cost about 131.0 €. But how long is the train ride from Città di Castello to Ragusa? Your journey takes about 19 hours on average.