Comiso to Mazara del Vallo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Comiso and arrive at Mazara del Vallo every about 12 hours on average. If travelling with Trenitalia, you need to know the Comiso to Mazara del Vallo train schedule: the first train leaves at 04:40, while the last ride is at 04:40. A Comiso to Mazara del Vallo train cost about 19.1 €. But how long is the train ride from Comiso to Mazara del Vallo? Your journey takes about 13 hours on average.