Comiso to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Comiso and arrive at Messina Centrale every about 6 hours on average. If travelling with Trenitalia, you need to know the Comiso to Messina train schedule: the first train leaves at 07:09, while the last ride is at 07:09. A Comiso to Messina train cost about 28.0 €. But how long is the train ride from Comiso to Messina? Your journey takes about 6 hours on average.