Como to Marsala trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Como S. Giovanni and arrive at Spagnuola every about 12 hours on average. If travelling with Trenitalia, you need to know the Como to Marsala train schedule: the first train leaves at 17:13, while the last ride is at 17:13. A Como to Marsala train cost about 161.9 €. But how long is the train ride from Como to Marsala? Your journey takes about 21 hours on average.