Como to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Como S. Giovanni and arrive at Palermo Notarbartolo every about 4 hours on average. If travelling with Trenitalia, you need to know the Como to Palermo train schedule: the first train leaves at 13:13, while the last ride is at 19:13. A Como to Palermo train cost about 112.3 €. But how long is the train ride from Como to Palermo? Your journey takes about 20 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Como to Palermo and find low cost tickets starting from 74 €!