Como to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Como S. Giovanni and arrive at Palermo Notarbartolo every about 4 hours on average. If travelling with Trenitalia, you need to know the Como to Palermo train schedule: the first train leaves at 13:13, while the last ride is at 19:13. A Como to Palermo train cost about 112.3 €. But how long is the train ride from Como to Palermo? Your journey takes about 20 hours on average.