Cremona to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Cremona and arrive at Messina Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Cremona to Messina train schedule: the first train leaves at 06:58, while the last ride is at 21:33. A Cremona to Messina train cost about 66.3 €. But how long is the train ride from Cremona to Messina? Your journey takes about 16 hours on average.