Cuneo to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Cuneo and arrive at Messina Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Cuneo to Messina train schedule: the first train leaves at 05:24, while the last ride is at 20:12. A Cuneo to Messina train cost about 114.0 €. But how long is the train ride from Cuneo to Messina? Your journey takes about 17 hours on average.