Desenzano del Garda to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Desenzano del Garda-Sirmione and arrive at Messina Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Desenzano del Garda to Messina train schedule: the first train leaves at 06:05, while the last ride is at 22:51. A Desenzano del Garda to Messina train cost about 109.75 €. But how long is the train ride from Desenzano del Garda to Messina? Your journey takes about 15 hours on average.