Desenzano del Garda to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Desenzano del Garda-Sirmione and arrive at Messina Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Desenzano del Garda to Messina train schedule: the first train leaves at 06:05, while the last ride is at 22:51. A Desenzano del Garda to Messina train cost about 109.75 €. But how long is the train ride from Desenzano del Garda to Messina? Your journey takes about 15 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Desenzano del Garda to Messina and find low cost tickets starting from 53 €!