Desenzano del Garda to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Desenzano del Garda-Sirmione and arrive at Niscemi every about 3 hours on average. If travelling with Trenitalia, you need to know the Desenzano del Garda to Niscemi train schedule: the first train leaves at 06:51, while the last ride is at 23:52. A Desenzano del Garda to Niscemi train cost about 111.1 €. But how long is the train ride from Desenzano del Garda to Niscemi? Your journey takes about 14 hours on average.