Desenzano del Garda to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Desenzano del Garda-Sirmione and arrive at Palermo Notarbartolo every about 2 hours on average. If travelling with Trenitalia, you need to know the Desenzano del Garda to Palermo train schedule: the first train leaves at 16:51, while the last ride is at 22:51. A Desenzano del Garda to Palermo train cost about 107.75 €. But how long is the train ride from Desenzano del Garda to Palermo? Your journey takes about 20 hours on average.