Desio to Caltanissetta trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Desio and arrive at Caltanissetta Centrale every about 4 hours on average. If travelling with Trenitalia, you need to know the Desio to Caltanissetta train schedule: the first train leaves at 16:24, while the last ride is at 19:24. A Desio to Caltanissetta train cost about 81.0 €. But how long is the train ride from Desio to Caltanissetta? Your journey takes about 12 hours on average.