Desio to Castelvetrano trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Desio and arrive at Castelvetrano every about 2 hours on average. If travelling with Trenitalia, you need to know the Desio to Castelvetrano train schedule: the first train leaves at 07:24, while the last ride is at 22:15. A Desio to Castelvetrano train cost about 115.85 €. But how long is the train ride from Desio to Castelvetrano? Your journey takes about 12 hours on average.