Desio to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Desio and arrive at Messina Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Desio to Messina train schedule: the first train leaves at 07:09, while the last ride is at 21:39. A Desio to Messina train cost about 71.5 €. But how long is the train ride from Desio to Messina? Your journey takes about 15 hours on average.