Desio to Milazzo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Desio and arrive at Milazzo every about 1 hour on average. If travelling with Trenitalia, you need to know the Desio to Milazzo train schedule: the first train leaves at 07:24, while the last ride is at 22:15. A Desio to Milazzo train cost about 104.7 €. But how long is the train ride from Desio to Milazzo? Your journey takes about 17 hours on average.