Desio to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Desio and arrive at Niscemi every about 4 hours on average. If travelling with Trenitalia, you need to know the Desio to Niscemi train schedule: the first train leaves at 18:09, while the last ride is at 19:39. A Desio to Niscemi train cost about 113.05 €. But how long is the train ride from Desio to Niscemi? Your journey takes about 9 hours on average.