Desio to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Desio and arrive at Palermo Notarbartolo every about 2 hours on average. If travelling with Trenitalia, you need to know the Desio to Palermo train schedule: the first train leaves at 13:39, while the last ride is at 19:39. A Desio to Palermo train cost about 109.7 €. But how long is the train ride from Desio to Palermo? Your journey takes about 20 hours on average.