Desio to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Desio and arrive at Siracusa every about 2 hours on average. If travelling with Trenitalia, you need to know the Desio to Syracuse train schedule: the first train leaves at 07:24, while the last ride is at 21:39. A Desio to Syracuse train cost about 71.5 €. But how long is the train ride from Desio to Syracuse? Your journey takes about 18 hours on average.