Domodossola to Acireale trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Domodossola and arrive at Acireale every about 3 hours on average. If travelling with Trenitalia, you need to know the Domodossola to Acireale train schedule: the first train leaves at 04:54, while the last ride is at 16:54. A Domodossola to Acireale train cost about 120.9 €. But how long is the train ride from Domodossola to Acireale? Your journey takes about 18 hours on average.