Domodossola to Alpignano trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Domodossola and arrive at Alpignano every 60 minutes on average. If travelling with Trenitalia, you need to know the Domodossola to Alpignano train schedule: the first train leaves at 04:54, while the last ride is at 19:02. A Domodossola to Alpignano train cost about 13 €. But how long is the train ride from Domodossola to Alpignano? Your journey takes about 3 hours on average.