Domodossola to Ancona trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Domodossola and arrive at Ancona every 60 minutes on average. If travelling with Trenitalia, you need to know the Domodossola to Ancona train schedule: the first train leaves at 04:54, while the last ride is at 18:54. A Domodossola to Ancona train cost about 49.5 €. But how long is the train ride from Domodossola to Ancona? Your journey takes about 6 hours on average.