Domodossola to Ancona trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 14 daily rides to get from Domodossola to Ancona. Trains leave from Domodossola and arrive at Ancona every 60 minutes on average. If travelling with Trenitalia, you need to know the Domodossola to Ancona train schedule: the first train leaves at 04:54, while the last ride is at 18:54. A Domodossola to Ancona train cost about 49.5 €. But how long is the train ride from Domodossola to Ancona? Your journey takes about 6 hours on average.