Domodossola to Comiso trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 1 daily rides to get from Domodossola to Comiso. Trains leave from Domodossola and arrive at Comiso every about 12 hours on average. If travelling with Trenitalia, you need to know the Domodossola to Comiso train schedule: the first train leaves at 16:54, while the last ride is at 16:54. A Domodossola to Comiso train cost about 197.6 €. But how long is the train ride from Domodossola to Comiso? Your journey takes about 20 hours on average.