Domodossola to Comiso trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Domodossola and arrive at Comiso every about 12 hours on average. If travelling with Trenitalia, you need to know the Domodossola to Comiso train schedule: the first train leaves at 16:54, while the last ride is at 16:54. A Domodossola to Comiso train cost about 197.6 €. But how long is the train ride from Domodossola to Comiso? Your journey takes about 20 hours on average.