Domodossola to Enna trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Domodossola and arrive at Enna every about 4 hours on average. If travelling with Trenitalia, you need to know the Domodossola to Enna train schedule: the first train leaves at 16:54, while the last ride is at 18:54. A Domodossola to Enna train cost about 137.75 €. But how long is the train ride from Domodossola to Enna? Your journey takes about 14 hours on average.