Domodossola to Marsala trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 1 daily rides to get from Domodossola to Marsala. Trains leave from Domodossola and arrive at Mozia-Birgi every about 12 hours on average. If travelling with Trenitalia, you need to know the Domodossola to Marsala train schedule: the first train leaves at 16:54, while the last ride is at 16:54. A Domodossola to Marsala train cost about 217.95 €. But how long is the train ride from Domodossola to Marsala? Your journey takes about 21 hours on average.