Domodossola to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Domodossola and arrive at Messina Centrale every about 3 hours on average. If travelling with Trenitalia, you need to know the Domodossola to Messina train schedule: the first train leaves at 04:54, while the last ride is at 16:54. A Domodossola to Messina train cost about 118.8 €. But how long is the train ride from Domodossola to Messina? Your journey takes about 16 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Domodossola to Messina and find low cost tickets starting from 50 €!