Domodossola to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Domodossola and arrive at Messina Centrale every about 3 hours on average. If travelling with Trenitalia, you need to know the Domodossola to Messina train schedule: the first train leaves at 04:54, while the last ride is at 16:54. A Domodossola to Messina train cost about 118.8 €. But how long is the train ride from Domodossola to Messina? Your journey takes about 16 hours on average.