Domodossola to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Domodossola and arrive at Niscemi every about 4 hours on average. If travelling with Trenitalia, you need to know the Domodossola to Niscemi train schedule: the first train leaves at 16:54, while the last ride is at 18:54. A Domodossola to Niscemi train cost about 108.0 €. But how long is the train ride from Domodossola to Niscemi? Your journey takes about 11 hours on average.