Domodossola to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Domodossola and arrive at Palermo Notarbartolo every about 2 hours on average. If travelling with Trenitalia, you need to know the Domodossola to Palermo train schedule: the first train leaves at 12:54, while the last ride is at 18:54. A Domodossola to Palermo train cost about 117.8 €. But how long is the train ride from Domodossola to Palermo? Your journey takes about 10 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Domodossola to Palermo and find low cost tickets starting from 73 €!