Domodossola to Palermo trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 7 daily rides to get from Domodossola to Palermo. Trains leave from Domodossola and arrive at Palermo Notarbartolo every about 2 hours on average. If travelling with Trenitalia, you need to know the Domodossola to Palermo train schedule: the first train leaves at 12:54, while the last ride is at 18:54. A Domodossola to Palermo train cost about 117.8 €. But how long is the train ride from Domodossola to Palermo? Your journey takes about 10 hours on average.