Domodossola to Ragusa trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 5 daily rides to get from Domodossola to Ragusa. Trains leave from Domodossola and arrive at Ragusa every about 2 hours on average. If travelling with Trenitalia, you need to know the Domodossola to Ragusa train schedule: the first train leaves at 12:54, while the last ride is at 16:54. A Domodossola to Ragusa train cost about 123.55 €. But how long is the train ride from Domodossola to Ragusa? Your journey takes about 12 hours on average.