Domodossola to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Domodossola and arrive at Siracusa every about 3 hours on average. If travelling with Trenitalia, you need to know the Domodossola to Syracuse train schedule: the first train leaves at 04:54, while the last ride is at 16:54. A Domodossola to Syracuse train cost about 122.3 €. But how long is the train ride from Domodossola to Syracuse? Your journey takes about 19 hours on average.