Domodossola to Trapani trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Domodossola and arrive at Trapani every about 12 hours on average. If travelling with Trenitalia, you need to know the Domodossola to Trapani train schedule: the first train leaves at 16:54, while the last ride is at 16:54. A Domodossola to Trapani train cost about 254.9 €. But how long is the train ride from Domodossola to Trapani? Your journey takes about 22 hours on average.