Empoli to Comiso trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Empoli and arrive at Comiso every about 2 hours on average. If travelling with Trenitalia, you need to know the Empoli to Comiso train schedule: the first train leaves at 06:01, while the last ride is at 22:33. A Empoli to Comiso train cost about 99.0 €. But how long is the train ride from Empoli to Comiso? Your journey takes about 14 hours on average.