Empoli to Milazzo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Empoli and arrive at Milazzo every about 1 hour on average. If travelling with Trenitalia, you need to know the Empoli to Milazzo train schedule: the first train leaves at 06:01, while the last ride is at 22:33. A Empoli to Milazzo train cost about 86.05 €. But how long is the train ride from Empoli to Milazzo? Your journey takes about 15 hours on average.