Empoli to Niscemi trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 1 daily rides to get from Empoli to Niscemi. Trains leave from Empoli and arrive at Niscemi every about 12 hours on average. If travelling with Trenitalia, you need to know the Empoli to Niscemi train schedule: the first train leaves at 19:32, while the last ride is at 19:32. A Empoli to Niscemi train cost about 257.95 €. But how long is the train ride from Empoli to Niscemi? Your journey takes about 21 hours on average.