Empoli to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Empoli and arrive at Niscemi every about 12 hours on average. If travelling with Trenitalia, you need to know the Empoli to Niscemi train schedule: the first train leaves at 19:32, while the last ride is at 19:32. A Empoli to Niscemi train cost about 257.95 €. But how long is the train ride from Empoli to Niscemi? Your journey takes about 21 hours on average.