Empoli to Palermo trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 7 daily rides to get from Empoli to Palermo. Trains leave from Empoli and arrive at Palermo Notarbartolo every about 2 hours on average. If travelling with Trenitalia, you need to know the Empoli to Palermo train schedule: the first train leaves at 16:21, while the last ride is at 22:33. A Empoli to Palermo train cost about 96.0 €. But how long is the train ride from Empoli to Palermo? Your journey takes about 18 hours on average.