Enna to Manfredonia trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Salerno, Enna and arrive at Manfredonia every about 2 hours on average. If travelling with Trenitalia, you need to know the Enna to Manfredonia train schedule: the first train leaves at 13:07, while the last ride is at 21:19. A Enna to Manfredonia train cost about 13.5 €. But how long is the train ride from Enna to Manfredonia? Your journey takes about 8 hours on average.