Florence to Caltanissetta trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Firenze S. M. Novella and arrive at Caltanissetta Centrale every about 3 hours on average. If travelling with Trenitalia, you need to know the Florence to Caltanissetta train schedule: the first train leaves at 21:57, while the last ride is at 21:57. A Florence to Caltanissetta train cost about 120.2 €. But how long is the train ride from Florence to Caltanissetta? Your journey takes about 20 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Florence to Caltanissetta and find low cost tickets starting from 114 €!