Florence to Comiso trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Firenze S. M. Novella and arrive at Comiso every about 6 hours on average. If travelling with Trenitalia, you need to know the Florence to Comiso train schedule: the first train leaves at 20:04, while the last ride is at 21:57. A Florence to Comiso train cost about 103.5 €. But how long is the train ride from Florence to Comiso? Your journey takes about 20 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Florence to Comiso and find low cost tickets starting from 62 €!