Florence to Comiso trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 2 daily rides to get from Florence to Comiso. Trains leave from Firenze S. M. Novella and arrive at Comiso every about 6 hours on average. The trip by train from Florence to Comiso last on average 16:43 travelling with high-speed trains (Frecciarossa or Italotreno) If travelling with Trenitalia, you need to know the Florence to Comiso train schedule: the first train leaves at 20:04, while the last ride is at 21:57. A Florence to Comiso train cost about 103.5 €. But how long is the train ride from Florence to Comiso? Your journey takes about 20 hours on average.