Florence to Marsala trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 3 daily rides to get from Florence to Marsala. Trains leave from Firenze S. M. Novella and arrive at Mozia-Birgi every about 4 hours on average. The trip by train from Florence to Marsala last on average 18:02 travelling with high-speed trains (Frecciarossa or Italotreno) If travelling with Trenitalia, you need to know the Florence to Marsala train schedule: the first train leaves at 20:04, while the last ride is at 21:57. A Florence to Marsala train cost about 84.45 €. But how long is the train ride from Florence to Marsala? Your journey takes about 21 hours on average.