Florence to Milazzo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Firenze S. M. Novella and arrive at Milazzo every about 2 hours on average. If travelling with Trenitalia, you need to know the Florence to Milazzo train schedule: the first train leaves at 10:04, while the last ride is at 21:57. A Florence to Milazzo train cost about 110.5 €. But how long is the train ride from Florence to Milazzo? Your journey takes about 12 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Florence to Milazzo and find low cost tickets starting from 55 €!