Florence to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Firenze S. M. Novella and arrive at Niscemi every about 4 hours on average. If travelling with Trenitalia, you need to know the Florence to Niscemi train schedule: the first train leaves at 17:09, while the last ride is at 21:09. A Florence to Niscemi train cost about 95.3 €. But how long is the train ride from Florence to Niscemi? Your journey takes about 12 hours on average.