Frosinone to Alessandria trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Frosinone and arrive at Alessandria every 60 minutes on average. If travelling with Trenitalia, you need to know the Frosinone to Alessandria train schedule: the first train leaves at 05:00, while the last ride is at 17:10. A Frosinone to Alessandria train cost about 58.5 €. But how long is the train ride from Frosinone to Alessandria? Your journey takes about 8 hours on average.