Frosinone to Caltanissetta trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Frosinone and arrive at Caltanissetta Centrale every about 4 hours on average. If travelling with Trenitalia, you need to know the Frosinone to Caltanissetta train schedule: the first train leaves at 05:41, while the last ride is at 19:20. A Frosinone to Caltanissetta train cost about 85.0 €. But how long is the train ride from Frosinone to Caltanissetta? Your journey takes about 15 hours on average.