Frosinone to Comiso trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Frosinone and arrive at Comiso every about 3 hours on average. If travelling with Trenitalia, you need to know the Frosinone to Comiso train schedule: the first train leaves at 06:01, while the last ride is at 20:23. A Frosinone to Comiso train cost about 88.0 €. But how long is the train ride from Frosinone to Comiso? Your journey takes about 15 hours on average.