Frosinone to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Frosinone and arrive at Palermo Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Frosinone to Palermo train schedule: the first train leaves at 05:00, while the last ride is at 20:21. A Frosinone to Palermo train cost about 64.0 €. But how long is the train ride from Frosinone to Palermo? Your journey takes about 14 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Frosinone to Palermo and find low cost tickets starting from 64 €!