Frosinone to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Frosinone and arrive at Siracusa every about 2 hours on average. If travelling with Trenitalia, you need to know the Frosinone to Syracuse train schedule: the first train leaves at 05:00, while the last ride is at 20:21. A Frosinone to Syracuse train cost about 64.0 €. But how long is the train ride from Frosinone to Syracuse? Your journey takes about 13 hours on average.