Genoa to Caltanissetta trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Genova Piazza Principe and arrive at Caltanissetta Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Genoa to Caltanissetta train schedule: the first train leaves at 17:04, while the last ride is at 23:53. A Genoa to Caltanissetta train cost about 114.4 €. But how long is the train ride from Genoa to Caltanissetta? Your journey takes about 20 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Genoa to Caltanissetta and find low cost tickets starting from 119 €!