Genoa to Castelvetrano trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Genova Piazza Principe and arrive at Castelvetrano every about 3 hours on average. If travelling with Trenitalia, you need to know the Genoa to Castelvetrano train schedule: the first train leaves at 14:52, while the last ride is at 23:53. A Genoa to Castelvetrano train cost about 76.65 €. But how long is the train ride from Genoa to Castelvetrano? Your journey takes about 17 hours on average.